Vitexin suppresses the proliferation, angiogenesis and stemness of endometrial cancer through the PI3K/AKT pathway
Endometrial cancer is a common gynecologic malignancy. Vitexin is an active flavonoid compound with an antitumor function. This study elucidated the role of vitexin in endometrial cancer development and clarified the potential mechanism. The toxicity of vitexin (0-80 μM) treatment for 24 h on HEC-1B and Ishikawa cells was tested utilizing the CCK-8 assay. Endometrial cancer cells were divided into vitexin 0, 5, 10, and 20 μM groups. Cell proliferation, angiogenesis and stemness Vitexin suppressed cell viability of HEC-1B (IC Vitexin has therapeutic potential on endometrial cancer, which supports further clinical trials.