Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study

Xiwen Liu & Jianxing He et al. · 2023-11-07

15Citations
TL;DR

Investigating the potential causative relationship between testosterone and sex hormone-binding globulin levels and the onset of several cancers indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer, and the corresponding genes of the identified SNPs were involved in significant metabolic and proliferative pathways.

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