DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection

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doi:10.1158/1078-0432.CCR-20-3331

DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection

Charles A. Ishak & Daniel D. De Carvalho · 2020-09-28

Abstract

Genome-wide DNA methylation profiles of serous tubal intraepithelial carcinomas (STIC) resemble methylation profiles of high-grade serous ovarian carcinomas (HGSOC) more closely than normal fallopian tube epithelium. While STICs and HGSOCs share subsets of common hypermethylated regions, DNA methylation can distinguish STICs from HGSOCs to provide proof-of-principle that DNA methylation can identify HGSOC initiation.

See related article by Pisanic et al., p. 6310

Links

DOI PubMed

Journal

Clinical Cancer Research

Authors

Charles A. Ishak, Daniel D. De Carvalho

Funding

CIHR

201512MSH-360794-228629

CIHR

PJT-165986

CIHR

MFE-164724

Canada Research Chairs

950-231346