Leflunomide Treatment Does Not Protect Neural Cells following Oxygen-Glucose Deprivation (OGD) In Vitro

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doi:10.3390/cells13070631

Leflunomide Treatment Does Not Protect Neural Cells following Oxygen-Glucose Deprivation (OGD) In Vitro

Claire J. M. Curel & Claire Thornton et al. · 2024

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TL;DR

Treating C17.2 cells with Leflunomide before or after oxygen-glucose deprivation to determine its efficacy as a neuroprotection and inhibitor of mitochondrial dysfunction confirmed that the tissue and mitochondrial protein profile of the target cell/tissue are critical for taking advantage of the therapeutic actions of Leflunomide.

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Authors

Claire J. M. Curel, Irene Nobeli, Claire Thornton