USP39 at the crossroads of cancer immunity: regulating immune evasion and immunotherapy response through RNA splicing and ubiquitin signaling

Feilong Zhou & Zhenyu He et al. · 2025

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TL;DR

A comprehensive analysis of the structural domains and functional properties of USP39, a detailed investigation into its interaction mechanisms with diverse substrates, and the accelerated development of related inhibitors will provide a novel theoretical foundation for the treatment of numerous diseases, including tumors.

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Authors
Feilong Zhou, Xinhao Li, Yanmei Sun, Yizhu Wang, Kaiyi Niu, Xin Gao, Jiaqi Zhang, Tianyi Chen, Yunxin Li, Weijie Zhao, Binyue Mao, Qiyang Xu, Yanlong Shi, Zhenyu He