TL;DR
It is demonstrated that the expression and activation of the mitochondrial fission mediator DRP1 are affected by chemotherapy exposure in common pediatric sarcomas, namely, rhabdomyosarcoma and osteosarcoma, and markedly reduced AMPKα1 levels are sufficient to maintain AMPK signaling capacity without affecting chemosensitivity.
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Authors
Karolina Borankova, Matyas Solny, Maria Krchniakova, Jan Skoda
