MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma

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doi:10.1111/cas.16151

MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma

Zhiduan Cai & Guibin Xu et al. · 2024

6Citations

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TL;DR

It was found that mitofusin 2 (MFN2) was downregulated in ccRCC tissues and associated with poor prognosis in patients with ccRCC, and MFN2 suppressed disease progression and improved prognosis for patients with ccRCC possibly by interrupting cellular lipid metabolism and reducing accumulation of lipid droplets.

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Authors

Zhiduan Cai, Wenjun Luo, Haoran Wang, Rui Zhu, Yaoji Yuan, Xiangyu Zhan, Mengyuan Xie, Haoquan Zhuang, Haoyu Chen, Yuyu Xu, Xiezhao Li, Leyuan Liu, Guibin Xu