TL;DR
How metabolic adaptations in cancer contribute to tumour progression entail high spatial and temporal metabolic heterogeneity, based on local adaptations in different regions of the tumour microenvironment, as well as metabolic evolution over time as the tumour progresses and metastasizes.
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Authors
Margherita Demicco, Xiao-Zheng Liu, Katharina Leithner, Sarah-Maria Fendt