Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm.

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doi:10.1016/j.phymed.2024.155696

Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm.

Jiami Zou & Zhiping Liu et al. · 2024

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TL;DR

Pt, a naturally occurring polyphenol and resveratrol analogue, shows promising efficacy for the treatment of AAA by targeting the KEAP1-Nrf2-STING axis in VSMCs.

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Authors

Jiami Zou, Zhihua Zheng, Weile Ye, Mei Jin, Pinglian Yang, Peter J Little, Jiaojiao Wang, Zhiping Liu