Sulfur dioxide increases testosterone biosynthesis by activating ERK1/2 pathway and disrupting autophagy in Leydig cells.

Xiang Li & Jianhai Zhang et al. · 2024

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TL;DR

It is suggested that SO2 promotes testosterone production by activating ERK1/2 and disrupting autophagy, which is enriched the dose-effect relationship of SO2 on the male reproductive system and provided a theoretical reference for a comprehensive and dynamic understanding of the SO2 toxic mechanism.

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Authors
Xiang Li, Yan Shi, Sha Liu, Zhiyuan Feng, Haoran Xiao, Rui Li, Zirou Li, Xinyue Zhang, Yongli Han, Jundong Wang, Chen Liang, Jian Bai, Jianhai Zhang