Integrated network analysis and experimental verification of the mechanisms employed by Compound Jixuecao Decoction to improve endoplasmic reticulum stress and apoptosis in chronic renal failure.

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doi:10.1016/j.jep.2024.117959

Integrated network analysis and experimental verification of the mechanisms employed by Compound Jixuecao Decoction to improve endoplasmic reticulum stress and apoptosis in chronic renal failure.

Huihong Zheng & De Jin et al. · 2024

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TL;DR

Evidence is provided that CJD effectively delays CFR through modulation of the MFN2 and PERK-eIF2α-ATF4-CHOP signaling pathways through modulation of the MFN2 and PERK-eIF2α-ATF4-CHOP signaling pathways.

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Authors

Huihong Zheng, Jiali Zeng, Peng Bi, Wanyue Xu, Yazhen Yang, Hongyu Chen, De Jin