Xanthoceras sorbifolium leaves alleviate hyperuricemic nephropathy by inhibiting the PI3K/AKT signaling pathway to regulate uric acid transport.

Yuchao Liu & Minhui Li et al. · 2024

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TL;DR

Evidence that X. sorbifolium Bunge extract alleviates HN is provided, and the potential mechanism underlying this effect may be the regulation of UA transporters, such as GLUT9 and URAT1, by limiting the activation of the PI3K/AKT signaling pathway to improve renal injury.

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Authors
Yuchao Liu, Yunqi Han, Yuquan Liu, Congying Huang, Wanze Feng, Hongwei Cui, Minhui Li