Myricetin alleviates renal tubular epithelial-mesenchymal transition via NOX4/NF-κB/snail axis in diabetic nephropathy based on network pharmacology analysis

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doi:10.1016/j.heliyon.2024.e35234

Myricetin alleviates renal tubular epithelial-mesenchymal transition via NOX4/NF-κB/snail axis in diabetic nephropathy based on network pharmacology analysis

Ningning Yuan & Wei Xiao et al. · 2024

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TL;DR

The mechanism underlying Myricetin's modulation of EMT in DN through disrupting the NOX4-NF-κB-Snail axis is unveiled, contributing a new therapeutic avenue for DN treatment and underscore the utility of network pharmacology in advancing drug discovery processes.

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Authors

Ningning Yuan, Yuchi Chen, Yangtian Yan, Fujing Wang, Xinyao Xu, Mingqing Wang, Jianxin Diao, Wei Xiao