The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo.

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doi:10.1016/j.ecoenv.2024.116465

The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo.

Wenzheng Yuan & Huanhuan Hu et al. · 2024

14Citations

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TL;DR

The reproductive toxicological effect of 5-FU on mice and its mechanism, provided basic data reference for adverse ecological and human health outcomes associated with 5-FU contamination or poisoning, and revealed the important role of ROS in testicular dysfunction caused by 5-FU.

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Authors

Wenzheng Yuan, Guojie Ji, Xiaowei Shi, Zhibin Sun, Chenyan Liu, Yangyang Yu, Wenmi Li, Xiaoyi Wang, Huanhuan Hu