Knockdown of ERN1 disturbs the expression of phosphoserine aminotransferase 1 and related genes in glioblastoma cells.

Oleksandr H. Minchenko & Dmytro O. Minchenko et al. · 2024

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Investigating the impact of ERN1 inhibition on the expression of serine synthesis genes in U87MG glioblastoma cells found changes in the expression of phosphoserine aminotransferase 1 and other genes related to serine synthesis are mediated by diverse ERN1-dependent mechanisms and contributed to suppressed proliferation and enhanced invasiveness of ERN1 knockdown glioblastoma cell.

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Authors
Oleksandr H. Minchenko, Myroslava Y. Sliusar, Yevgen P. Khikhlo, Oleh V. Halkin, Yuliia M. Viletska, Olena O. Khita, Dmytro O. Minchenko