TL;DR
Investigating the impact of ERN1 inhibition on the expression of serine synthesis genes in U87MG glioblastoma cells found changes in the expression of phosphoserine aminotransferase 1 and other genes related to serine synthesis are mediated by diverse ERN1-dependent mechanisms and contributed to suppressed proliferation and enhanced invasiveness of ERN1 knockdown glioblastoma cell.
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Authors
Oleksandr H. Minchenko, Myroslava Y. Sliusar, Yevgen P. Khikhlo, Oleh V. Halkin, Yuliia M. Viletska, Olena O. Khita, Dmytro O. Minchenko