Complement factor B inhibitor LNP023 mediates the effect and mechanism of AMPK/mTOR on autophagy and oxidative stress in lupus nephritis

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doi:10.1002/kjm2.12894

Complement factor B inhibitor LNP023 mediates the effect and mechanism of AMPK/mTOR on autophagy and oxidative stress in lupus nephritis

Xi‐Mei Zhang & Liang Peng et al. · 2024

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TL;DR

The complement factor B inhibitor LNP023 promotes kidney health in LN mice by mediating the AMPK/mTOR pathway, promoting autophagy, and attenuating oxidative stress, with enhanced effects when combined with AICAR.

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Authors

Xi‐Mei Zhang, Ming‐Jie Qing, Xin‐Kuo Liu, Liang Peng