FOXO3 Activates MFN2 Expression to Maintain the Autophagy Response in Cancer Cells Under Amino Acid Deprivation

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doi:10.1002/jcb.30641

FOXO3 Activates MFN2 Expression to Maintain the Autophagy Response in Cancer Cells Under Amino Acid Deprivation

Xu Jiang & Yuyun Li et al. · 2024

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TL;DR

This work demonstrates that the FOXO3–MFN2 pathway is essential for adaptive changes in mitochondrial morphology and cellular autophagy response under nutritional constraints.

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Authors

Xu Jiang, Jing Wang, Fang Ma, Yuyun Li