Integrated spectral and depth compensation approach for optimizing oxygen saturation and total hemoglobin estimation in photoacoustic tomography for ovarian lesion diagnosis
Photoacoustic tomography (PAT) holds promise for non-invasive functional imaging in ovarian cancer diagnostics. However, accurate estimation of oxygen saturation ( We aim to improve the accuracy and clinical utility of We introduce a spectral compensation strategy derived from Monte Carlo simulations and integrate it with depth-wise fluence correction to construct the proposed ISDC method. The approach has been validated using phantoms with known optical properties and applied to clinical PAT data from 82 ovarian lesions (67 benign and 15 malignant). Diagnostic performance was evaluated using logistic regression and receiver operating characteristic analysis. In phantom experiments, ISDC improved The ISDC approach significantly enhances the quantitative accuracy and diagnostic performance of PAT by compensating for both spectral and depth fluence variations within biological tissue. These improvements support the integration of ISDC into US-PAT systems for ovarian lesion characterization and future clinical applications.