Noninvasive evaluation of HABP1 expression with 99m Tc-labeled small-interference RNA in ovarian cancer

Chunyu Duan & Changjiu Zhao et al. · 2021-08-31

2Citations
Ovarian cancer is one of the most common gynecological cancers in women with a low 5-year survival rate. Evaluation of hyaluronic acid-binding protein 1 (HABP1) level can provide important information for the diagnosis and treatment of ovarian cancer. In this study, we designed a novel HABP1 probe based on A specific siHABP1 was selected because of its targetability and silencing effect. A negative control siRNA (NCsiRNA) with no homology with the human genome was used. SiHABP1 and NCsiRNA were radiolabeled with We showed that
TL;DR

It is shown that 99mTc-HYNIC-siHABP1 is a feasible probe for the noninvasive visualization of HABP 1 expression in ovarian cancer, and showed the same binding capacity and silencing effect as siHabP1.

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