IL-10 + CD19 + regulatory B cells induce CD4 + Foxp3 + regulatory T cells in serum of cervical cancer patients

Chunfeng Yang & Xi Fu et al. · 2023-12-12

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Increase of regulatory T cells (Tregs) in the tumour microenvironment predicts worse survival of patients with various types of cancer. Recently, B cells play a significant role in the maintenance of Treg cells. However, the relevance of regulatory B cells (Bregs) to tumour immunity in humans remains elusive. Flow cytometry analysis was used to detect the Bregs and Tregs. Double staining results illustrated that the proportion of Bregs and Tregs were prominently higher in cervical cancer than normal tissues. Increase of Bregs and Tregs in cervical cancer microenvironment was associated with poor survival. Furthermore, Bregs cocultured with cervical cancer cell lines increased and induced Tregs. To sum up, the increased expression of Bregs contributes to the differentiation of CD4
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Autoimmunity
TL;DR

The increased expression of Bregs contributes to the differentiation of CD4+ T cells into Tregs in the cervical cancer.

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Authors
Chunfeng Yang, Yuanyuan Zhang, Rui Wang, Bing Cheng, You Wu, Xi Fu
Funding
Guangzhou Health Science and Technology Project Grant 20231A011097Youth Research Support Program of Third Affiliated Hospital of Guangzhou Medical University Grant 2017Q11Medical Science and Technology Project of Henan Province Grant LHGJ20190596Henan Province Technology Development Project Grant 202102310066