TCGA molecular subtypes in endometriosis-associated ovarian cancer: a systematic review and meta-analysis
Endometriosis-associated ovarian cancer (EAOC) mainly includes endometrioid ovarian cancer (ENOC) and clear cell ovarian cancer (CCOC). The Cancer Genome Atlas (TCGA) revealed four molecular subtypes of endometrial cancer (EC) in 2013, which have been proven pivotal in the diagnostic, prognostic and therapeutic domains of EC. Existing evidence indicates that EC and EAOC molecular analysis have similar significance. This review aims to investigate the distribution, staging and prognostic characteristics of molecular subtypes in EAOC. PubMed, Embase and Web of Science were systematically searched from January 2013 to December 2023 using predefined keywords. Patient characteristics, including stage and prognostic characteristics, were extracted from the selected studies. Data analysis was carried out using Stata 14MP. A total of 6 studies involving 1,133 patients with ENOC and 4 studies comprising 377 patients with CCOC were included. ENOC had a higher frequency of the POLE mutation (POLEmut) subtype (odds ratio (OR) = 2.29, 95% CI: 1.03-5.11, The TCGA subtypes of EC may exhibit similarities in prognosis between ENOC and CCOC.
Journal
Annals of MedicineInstitutions
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Funding
National Natural Science Foundation of China Grant 82302974Natural Science Foundation of Youth Fund Projects of Jiangsu Province Grant BK20210976Jiangsu Provincial Scientific Research and Health Project Grant ZD2022005Jiangsu Provincial Scientific research and Health Project for Women and Children Grant F202004Outstanding Talent Program of the Second Affiliated Hospital of Nanjing Medical University Grant 789ZYRC202080122Clinical Science and Technology Climbing Program-”Spark”Basic Research Project, The Affiliated Cancer Hospital of Nanjing Medical University Grant ZJ202213