β-1,3-glucan from
                    Euglena gracilis
                    : a promising epidrug targeting epigenetic regulators PRMTs and SIRTs for therapeutic applications in ovarian cancer

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doi:10.1080/07391102.2024.2425832

β-1,3-glucan from Euglena gracilis : a promising epidrug targeting epigenetic regulators PRMTs and SIRTs for therapeutic applications in ovarian cancer

Varsha Virendra Palol & Raj Kumar Chinnadurai et al. · 2024-11-13

1Citations

Natural products serve as a valuable resource in drug discovery and the identification of bioactive molecules in the field of epimedicine, which targets epigenetic regulator enzymes through epidrugs. In this study, β-1,3-glucan (BG), a natural storage polysaccharide in

Links

DOI PubMed

Journal

Journal of Biomolecular Structure and Dynamics

TL;DR

The molecular interactions between BG and epigenetic regulators, Protein Arginine Methyltransferases (PRMTs) and Sirtuins (SIRTs) were investigated using computational methods followed by in vitro gene expression studies in SKOV-3 ovarian cancer cell line to elucidate the therapeutic efficacy of BG against ovarian cancer.

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Authors

Varsha Virendra Palol, Kamran Waidha, Balasubramanian Moovarkumudalvan, Navya Valavath Baburajan, Suresh Kumar Saravanan, Divya Lakshmanan, Veni Subramanyam, Raj Kumar Chinnadurai