Single-molecule array assay reveals the prognostic impact of plasma LRIG1 in ovarian carcinoma
4Citations
Ovarian carcinoma is the eighth most common cause of cancer death in women worldwide. The disease is predominantly diagnosed at a late stage. This contributes to high recurrence rates, eventually leading to the development of treatment-resistant disease. Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is a transmembrane protein that functions as a tumor suppressor and regulator of growth factor signaling. LRIG1 levels have not been investigated in human plasma previously. A quantitative LRIG1-specific single molecule array assay was developed and validated. LRIG1 levels were quantified in plasma samples from 486 patients with suspicious ovarian masses. Among women with ovarian carcinoma, LRIG1 levels were significantly elevated compared to women with benign or borderline type tumors. High LRIG1 plasma levels were associated with worse overall survival and shorter disease-free survival both in the group of all malignant cases and among the stage 3 cases only. LRIG1 was an independent prognostic factor in patients with stage 3 ovarian carcinoma. LRIG1 plasma levels were elevated in patients with ovarian carcinoma, and high levels were associated with poor prognosis, suggesting that LRIG1 might be an etiologic factor and a potentially useful biomarker in ovarian carcinoma.
Journal
Acta OncologicaTL;DR
Authors
Funding
the Swedish Cancer Society Grant 2018/546the Swedish Cancer Society Grant 2018/384Lion’s Cancer Research Foundation at Umeå University Grant 20-2230Umeå University and Västerbotten County Council on the cooperation in the field of Medicine, Odontology and Health Grant 836951the Swedish state under the agreement between the Swedish Government ant the county councils, the Alf-agreement Grant 965552The Assar Gabrielsson Foundation FundingCancer Research Foundation in Northern Sweden Grant 21-1047Cancerfonden FundingStiftelsen Assar Gabrielssons Fond Funding