WIREs RNA

Nanocarrier‐delivered small interfering RNA for chemoresistant ovarian cancer therapy

AbstractOvarian cancer is the fifth leading cause of cancer‐related death in women in the United States. Because success in early screening is limited, and most patients with advanced disease develop resistance to multiple treatment modalities, the overall prognosis of ovarian cancer is poor. Despite the revolutionary role of surgery and chemotherapy in curing ovarian cancer, recurrence remains a major challenge in treatment. Thus, improving our understanding of the pathogenesis of ovarian cancer is essential for developing more effective treatments. In this review, we analyze the underlying molecular mechanisms leading to chemotherapy resistance. We discuss the clinical benefits and potential challenges of using nanocarrier‐delivered small interfering RNA to treat chemotherapy‐resistant ovarian cancer. We aim to elicit collaborative studies on nanocarrier‐delivered small interfering RNA to improve the long‐term survival rate and quality of life of patients with ovarian cancer.This article is categorized under: RNA Methods > RNA Nanotechnology Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action

RNA epigenetic modifications in ovarian cancer: The changes, chances, and challenges

AbstractOvarian cancer (OC) is the most common female cancer worldwide. Patients with OC have high mortality because of its complex and poorly understood pathogenesis. RNA epigenetic modifications, such as m6A, m1A, and m5C, are closely associated with the occurrence and development of OC. RNA modifications can affect the stability of mRNA transcripts, nuclear export of RNAs, translation efficiency, and decoding accuracy. However, there are few overviews that summarize the link between m6A RNA modification and OC. Here, we discuss the molecular and cellular functions of different RNA modifications and how their regulation contributes to the pathogenesis of OC. By improving our understanding of the role of RNA modifications in the etiology of OC, we provide new perspectives for their use in OC diagnosis and treatment.This article is categorized under: RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease