Organic & Biomolecular Chemistry

Synthesis of N-oxyamide analogues of protein kinase B (Akt) targeting anionic glycoglycerolipids and their antiproliferative activity on human ovarian carcinoma cells

N-Oxyamides of bioactive anionic glycoglycerolipids based on 2-O-β-d-glucosylglycerol were efficiently prepared. The N-oxyamide group could increase the antiproliferative activity of glycoglycerolipids.

A chalcone-based ESIPT and AIE fluorophore for β-gal imaging in living cells

The chalcone-based fluorescent probe gal-HCA favors highly selective detection of β-galactosidase in vitro and in living cells.

Solvent-free synthesis and in-silico molecular docking study of (E)-3-(β-C-glycosylmethylidene)-N-aryl/alkyl succinimides

Solvent-free synthesis of β-C-glycosylated methylidene succinimides using the Wittig olefination reaction and subsequent Lewis acid-mediated deprotection has been reported. Docking studies reveal that these compounds are selective and potent inhibitors of the E6 oncoprotein of high-risk type HPV16.

Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

This paper describes the synthesis and biological evaluation of new inhibitors of anti-apoptotic proteins towards novel anti-cancer agents.