Natural Product Research

Evaluation of the anticancer potential of secondary metabolites from Pseudevernia furfuracea based on epidermal growth factor receptor inhibition

UHPLC/ESI/MS/MS profiling followed by bioactivity guided isolation of

Urdamycin V from Streptomyces sp induces p53 independent apoptosis in cervical cancer cells inconsiderate of HPV status and inhibited growth of gram-positive human pathogens

In cervical cancer, loss of p53 or mutant non-functional p53 and hyperactivated mTOR/Akt pathway positively correlates to cancer progression. Urdamycin V isolated from

Synthesis of new boswellic acid derivatives as potential antiproliferative agents

In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-

New and bioactive polyketides from Hawaiian marine-derived fungus Trichoderma sp. FM652

Two new sorbicillinoid derivatives (

Limonoids and carbazole alkaloids from the twigs of Chalcas siamensis Tanaka

One new limonoid, named siamensinolide (

Chemical constituents fromOldenlandia diffusaand their cytotoxic effects on human cancer cell lines

Secundiflorol G isolated from Aeschynomene fascicularis, a Mayan medicinal plant, induces apoptosis in cervical cancer cells

Secundiflorol G (SG) is an isoflavan isolated from the root bark of

Two new alkaloids from Tibetan medicine of Hypecoum leptocarpum

Two new alkaloids, leptocarpinine B (

Synthesis of messagenin and platanic acid chalcone derivatives and their biological potential

The chalcone derivatives of 20-oxo-lupanes have been synthesised and screened for some types of biological activity. Ozonolysis of lupanes afforded 20-oxo-derivatives with the following condensation using different aromatic aldehydes by Claisen‒Schmidt reaction to the target compounds. The

Chemotaxonomy and cytotoxicity of the liverwortPorella Viridissima

The first chemotaxonomic study based on volatile components of

Diadema setosum: isolation of bioactive secondary metabolites with cytotoxic activity toward human cervical cancer

In our promising project toward discovery of secondary metabolites with potential anticancer activity against human cervical cancer, seven marine organisms were screened for their cytotoxic activity against HeLa cancer cell line using MTT colorimetric assay. The crude extract of the outer shell of

Bufogarlides A-C, three new bufadienolides with Δ 14,15 double bond from the skins of Bufo bufo gargarizans

Three new bufadienolides with a

Tumour growth inhibitory effect of Ibervillea sonorae phytopreparations in cervical cancer xenografts

Cucurbitacin IIb, a triterpene obtained from the

Phytochemical analysis and bioactivity reports of ethnomedicinal plants from West Bengal, India

The biodiversity-rich forests of the Jhargram subdivision of West Bengal, India houses many lesser-known prospective plants. Four ethnomedicinal plants from this locality-

Cell death induction by mycelium extracts from Pleurotus spp. on cervical cancer cell lines

Mushrooms have health benefits, including anti-tumoral properties. We evaluated the cytotoxic and cell death induction effects of water-soluble extracts of

Bixa orellana L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells in vitro

Emerging evidence on the potential pro-oxidant effect of carotenoids provokes apoptosis of cancer cells.

Analysis of metabolic compounds and antitumorigenic effects of Albizia niopoides and Senegalia polyphylla leaves

The objective of this study was to quantify metabolic compounds in leaves of

Research on the mechanisms of Shu Yu wan in the treatment of cervical cancer based on network pharmacology analyses and molecular docking technology

Combining network pharmacology with molecular docking, our study revealed the candidate targets and mechanisms of Shu Yu Wan (SYW) for treating cervical cancer (CC). The targets associated with CC and active compounds in SYW were identified through TCGA, GeneCards and TCMSP databases. Consequently, a total of 16 active compounds in SYW and 38 common targets related to CC were predicted. Genes TP53 and CDK2 are among the hub genes in the PPI network. The results of GO and KEGG enrichment analyses suggested that SYW exerted pharmacological effects on CC by regulating cellular senescence, p53 signaling pathway, cell cycle, apoptosis, viral carcinogenesis and human papillomavirus infection (HPV) signaling pathway. Finally, molecular docking confirmed a strong binding affinity between the main active compounds of SYW with the core target proteins.

Phytochemical screening, antimicrobial, antioxidant, anticancer activities on cervical cancer cell lines and aero-digestive extract of Moringa oleifera

The phytochemical screening showed that the

Cytotoxicity and anti-inflammatory effects of the extract, fractions and alkaloids from Palicourea minutiflora (Rubiaceae)

New prenylated flavonoid glycosides from the stems of Celastrus orbiculatus with their anti-tumor activities

Two new prenylated flavonoid glycosides (

A new cytotoxic polycyclic polyprenylated acylphloroglucinol from Garcinia nujiangensis screened by the LC-PDA and LC-MS

A new polycyclic polyprenylated acylphloroglucinol (