Lab on a Chip

An integrated microfluidic platform for detection of ovarian clear cell carcinoma mRNA biomarker FXYD2

Molecular diagnostic procedures including cancer cell isolation, RNA extraction, and qRT-PCR plus detection were automated on the integrated microfluidic system.

Optimization of aptamer selection on an automated microfluidic system with cancer tissues

Optimization of aptamer selection using tissue samples has been carried out on an automated microfluidic system and one screened aptamer exhibited high specificity and affinity towards ovarian cancer tissue.

Sequencing-free, joint single-EV profiling of DNA and protein cargos enables accurate cancer detection at early stages

Colocalization of DNA and protein markers reveals rare extracellular vesicle subpopulations for facile and affordable cancer diagnosis at early stages.

Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer

Ultrasensitive MIRACLE SlipChip platform for single-copy RNA biomarker detection in OC liquid biopsy.

An integrated microfluidic system for rapid, automatic and high-throughput staining of clinical tissue samples for diagnosis of ovarian cancer

An integrated microfluidic platform capable of labeling ovarian cancer biomarkers within formalin-fixed, paraffin embedded tissues via aptamer probes was developed.