Biomaterials Science

Antibody-functionalized theranostic protein nanoparticles for the synergistic deep red fluorescence imaging and multimodal therapy of ovarian cancer

This work presents novel phototheranostic protein nanoagents loaded with a newly synthesized deep red dye, revealing fluorescence imaging, photothermal and photodynamic features simultaneously upon targeted internalization within ovarian cancer cells.

Nano-assembly of ursolic acid with platinum prodrug overcomes multiple deactivation pathways in platinum-resistant ovarian cancer

A dual prodrug nano-assembled system for synergistic chemotherapy of platinum-resistant ovarian cancer.

PEGylated WS2 nanodrug system with erythrocyte membrane coating for chemo/photothermal therapy of cervical cancer

The side effects of chemical drugs and multi-drug resistance are serious obstacles hindering efficient tumor therapy.

Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging

As a multifunctional theranostic nanoplatform, FPCH-DOX NPs enable triple-stimuli responsive drug release for MR/thermal imaging-guided photothermal-chemo combination therapy.

Duo of (–)-epigallocatechin-3-gallate and doxorubicin loaded by polydopamine coating ZIF-8 in the regulation of autophagy for chemo-photothermal synergistic therapy

A pH- and photothermal-responsive zeolitic imidazolate framework (ZIF-8) compound was designed for loading a dual-drug in the tumor site and improving their curative effects.

Polyethyleneimine coated Fe3O4 magnetic nanoparticles induce autophagy, NF-κB and TGF-β signaling pathway activation in HeLa cervical carcinoma cells via reactive oxygen species generation

Fe3O4 magnetic nanoparticles (MNPs) are proved to induce autophagy, NF-κB and TGF-β signaling pathways activation in cancer cells, which is switched on by induced ROS.

Development of a nano-vaccine for high-grade serous ovarian cancer

An overview of the development of a vaccine for High-Grade Serous Carcinoma.

Enzyme-instructed assembly of a cholesterol conjugate promotes pro-inflammatory macrophages and induces apoptosis of cancer cells

Enzyme-instructed assembly that promotes pro-inflammatory macrophages and induces the apoptosis of cancer cells provides a unique method for combination therapy.

Core–shell hydrogel microspheres with sequential drug release and magnetothermal synergy for drug-resistant ovarian cancer

Ovarian cancer (OC) is one of the most fatal malignant tumors of the female reproductive system, and its high recurrence rate in advanced stages and drug resistance severely limit the efficacy of current treatment methods.