Australasian Journal of Dermatology

Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report

AbstractBilateral diffuse uveal melanocytic proliferation (B‐DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B‐DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear‐cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with ‘B‐DUMP’. Simultaneously, she developed multifocal bilateral bluish‐greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B‐DUMP be termed ‘diffuse integumentary melanocytic proliferation (DIMP)’.

A prospective, 12‐month observational study of attendance to a multidisciplinary tertiary vulvar clinic in South Australia

Myoepithelioma‐like tumour of the vulval region: A case report

AbstractMyoepithelioma‐like tumours of the vulvar region (MELTVR) are a newly described group of spindle cell neoplasm. Morphologically, they consist of epithelioid to spindled cells in a myxoid to collagenous stroma and can resemble epithelioid sarcomas, myoepithelial carcinomas or extraskeletal myxoid chondrosarcomas. However, they have a distinct pattern of immunohistochemical staining characterised by positivity for EMA, ER, PR and negativity for cytokeratin, GFAP and S100. Nuclear staining for INI‐1 is lost. In addition, they lack the characteristic gene arrangements of these other lesions. MELTVR can recur locally when incompletely excised, however, do not appear to metastasize. We report a case of a MELTVR in a 49‐year‐old woman arising in the right mons pubis.

Vulvar malignancy in biopsy‐proven vulval lichen planus: A retrospective review of 105 cases