ACS Infectious Diseases

The Role of Cervicovaginal Microbiota and Probiotics in Modulating HPV Persistence and Preventing Cervical Cancer

Cervical cancer (CC) is one of the leading causes of mortality in women worldwide, where the main risk factor is infection with the human papillomavirus (HPV). This type of cancer is a significant public health problem, especially in regions with limited access to health care and vaccination programs. In recent years, the crucial link between the cervicovaginal microbiota and immune homeostasis has been highlighted, emphasizing its protective role against infections, including HPV. The cervicovaginal microbiota is composed mostly of bacteria of the