Zhirong Yang

NIR Triggered Fluorescence Imaging and Synergistic Ablation of Cervical Cancer Using ICG-Loaded CuO Nanoleaves via Photothermal-Augmented ROS Amplification

Developing Cu-based nanocatalysts capable of generating sufficient reactive oxygen species (ROS) to effectively inhibit tumor cell growth remains a significant challenge. In this study, we introduce a distinctive copper oxide nanocarrier with a unique leaf-like lamina structure and layered mesopores. Indocyanine Green (ICG) is encapsulated within the mesopores, and poly(ethylene glycol) (PEG) groups are attached to the surface. This nanoplatform demonstrates efficient accumulation in tumor areas, serving as a near-infrared (NIR) fluorescent contrast agent for tumor imaging. Remarkably, under NIR laser irradiation, the nanoplatform exhibits high photothermal conversion efficiency, which enhances ROS production through localized heating. Both