Investigator

Zheng Zhang

Yuhuangding Hospital

ZZZheng Zhang
Papers(3)
Clinical Characterist…Cervical perineural c…SCAC: A Semi-Supervis…
Collaborators(7)
Liang ZengMingxiao ChenPengfei ShaoPeng YaoRonald X. XuShuo YuanShuwei Shen
Institutions(4)
Yuhuangding HospitalUnknown InstitutionUniversity of Science…Womens Hospital

Papers

Clinical Characteristics and Diagnostic-Therapeutic Analysis of Pulmonary Benign Metastasizing Leiomyoma: A 10-Case Retrospective Study and Systematic Review

Background Pulmonary benign metastasizing leiomyoma (PBML), characterized by histologically benign lung metastases from uterine leiomyomas, represents a rare hormone-dependent entity with enigmatic pathogenesis. The aim of the study was to define the clinical-radiological features and therapeutic management of pulmonary benign metastasizing leiomyoma. Methods A total of 115 cases of PBML in women were reviewed, including 105 cases selected from PubMed and 10 cases treated at our institution from 2014 to 2025. Data encompassed clinical history, imaging findings, pathological diagnosis, treatments, and follow-up outcomes. A comprehensive literature review was undertaken. No prospective interventions were performed. Results A systematic review identified 105 published PBML cases. Combined with our institutional cohort (n = 10), analysis of 115 patients revealed a median age of 46 years, with bilateral pulmonary nodules present in 68.7% of cases and a history of uterine surgery in 92.1%. Immunohistochemistry consistently showed positivity for smooth muscle markers (90%), estrogen receptor (86.3%), and progesterone receptor (88.2%). Surgical resection of pulmonary lesions was performed in 42.6% (49/115) of patients and was associated with a favorable prognosis, with 85.2% (41/48) of surgically managed patients achieving disease-free status during follow-up. Conclusion Pulmonary benign metastasizing leiomyoma is a rare hormone-dependent neoplasm linked to uterine leiomyoma. Pathological verification remains essential for diagnosis. Surgical resection may correlate with favorable outcomes, necessitating long-term recurrence surveillance.

SCAC: A Semi-Supervised Learning Approach for Cervical Abnormal Cell Detection

Cervical abnormal cell detection plays a crucial role in the early screening of cervical cancer. In recent years, some deep learning-based methods have been proposed. However, these methods rely heavily on large amounts of annotated images, which are time-consuming and labor-intensive to acquire, thus limiting the detection performance. In this paper, we present a novel Semi-supervised Cervical Abnormal Cell detector (SCAC), which effectively utilizes the abundant unlabeled data. We utilize Transformer as the backbone of SCAC to capture long-range dependencies to mimic the diagnostic process of pathologists. In addition, in SCAC, we design a Unified Strong and Weak Augment strategy (USWA) that unifies two data augmentation pipelines, implementing consistent regularization in semi-supervised learning and enhancing the diversity of the training data. We also develop a Global Attention Feature Pyramid Network (GAFPN), which utilizes the attention mechanism to better extract multi-scale features from cervical cytology images. Notably, we have created an unlabeled cervical cytology image dataset, which can be leveraged by semi-supervised learning to enhance detection accuracy. To the best of our knowledge, this is the first publicly available large unlabeled cervical cytology image dataset. By combining this dataset with two publicly available annotated datasets, we demonstrate that SCAC outperforms other existing methods, achieving state-of-the-art performance. Additionally, comprehensive ablation studies are conducted to validate the effectiveness of USWA and GAFPN. These promising results highlight the capability of SCAC to achieve high diagnostic accuracy and extensive clinical applications.

1Works
3Papers
7Collaborators