Investigator

Yungang Xu

Professor · Xi'an Jiaotong University

About

YXYungang Xu
Papers(1)
The global burden, tr…
Collaborators(1)
Ruixia Yuan
Institutions(2)
Xian Jiaotong Univers…The First Affiliated …

Papers

The global burden, trends and cross‐country inequalities of female breast and gynaecologic cancers: A population based study

AbstractObjectiveTo analyse the global burden, trends and cross‐country inequalities of female breast and gynaecologic cancers (FeBGCs).DesignPopulation‐Based Study.SettingData sourced from the Global Burden of Disease Study 2019.PopulationIndividuals diagnosed with FeBGCs.MethodsAge‐standardised mortality rates (ASMRs), age‐standardised Disability‐Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age‐standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index.Main Outcome MeasuresThe main outcome measures were the burden of FeBGCs and the trends in its inequalities over time.ResultsIn 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30–510.51), cervical cancer: 210.64 (95% UI: 177.67–234.85), ovarian cancer: 124.68 (95% UI: 109.13–138.67) and uterine cancer: 210.64 (95% UI: 177.67–234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: −0.51 (95% CI: −0.57 to −0.45); Cervical cancer: −0.95 (95% CI: −0.99 to −0.89); Ovarian cancer: −0.08 (95% CI: −0.12 to −0.04); and Uterine cancer: −0.84 (95% CI: −0.93 to −0.75). In the Social Inequalities Analysis (1990–2019) the SII changed from 689.26 to 607.08 for Breast, from −226.66 to −239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4.ConclusionsThe burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio‐demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.

38Works
1Papers
1Collaborators
NeoplasmsLiver NeoplasmsCarcinoma, HepatocellularTumor MicroenvironmentBreast NeoplasmsGenital Neoplasms, FemaleGlobal Burden of Disease

Positions

2021–

Professor

Xi'an Jiaotong University

2019–

Postdoc Research Fellow

Children's Hospital of Philadelphia

2015–

Postdoctoral Fellow

Wake Forest University School of Medicine · Bioinformatics

Education

2014

PhD

Harbin Institute of Technology · School of Computer Science and Technology, School of Life Science and Technology

2010

M.D.

Northeast Forestry University · School of Life Science

2007

B.A.

Northeast Forestry University · School of Life Science

Keywords
BioinformaticsComputational BiologyPlant BiologyCancer genomicsStem cell differentiationAl