Investigator

Yongwimon Lenbury

Professor · Mahidol University Faculty of Science, Department of Mathematics

About

YLYongwimon Lenbury
Papers(1)
Survival Analysis of …
Institutions(1)
Mahidol University

Papers

Survival Analysis of Cervical Cancer Patients: A Case Study of Bhutan

The purpose of the study is to identify the risk factors such as age, the stage of patients based on the International Federation of Gynecology and Obstetrics system (FIGO stage) and treatment type, and their effect on the survival of cervical cancer patients receiving treatments at Jigme Dorji Wangchuck National Referral Hospital (JDWNRH) in Bhutan between January 2014 and December 2019. In this retrospective study, all 357 women diagnosed with cervical cancer were included. Kaplan-Meier model was applied to estimate survival, and the log-rank test was performed to compare survival distributions between subgroups stratified by each of the risk factors. Baseline demographics, cervical cancer stages, and treatment options were analyzed as factors and predictors of survival by Cox proportional hazards model. The overall estimated 1- to 5-year survival rates are 82.1% (95% CI: 77.8-86.7), 75.6% (70.4-81.1), 65.2% (58.2-73.0), 62.3% (54.7-70.9) and 55.4% (44.9-68.3). The results reveal that age group, FIGO stage, treatment, and frequency of hospital visits are significant factors affecting the survival of cervical cancer patients in Bhutan. Patients aged >45 years increases the risk of dying (HR: 2.1, 95% CI: 1.2-3.9) compared to the young age group (≤45 years). Treatment types other than surgery only are significantly associated with an increased risk of mortality in patients with cervical cancers. The more frequency of hospital visits also reduces the risk of dying (HR: 0.1, 95% CI: 0-0.3). FIGO stage IV is the most significant risk factor for mortality with a hazard ratio of 6 (95% CI: 2.1-17.6). The five-year survival rate of cervical cancer patients in this study was low. Late diagnosis of cervical cancer appears to be mainly associated with a higher risk of dying. The results provide valuable information for further research and policymaking in the prevention and management of cervical cancer. .

39Works
1Papers
Neoplasm StagingUterine Cervical Neoplasms

Positions

1996–

Professor

Mahidol University Faculty of Science · Department of Mathematics

2006–

Chair, Ph.D Executive Programme Committee

Mahidol University Faculty of Science · Department of Mathematics

1998–

Chairman

Mahidol University Faculty of Science · Department of Mathematics

1990–

Associate Professor

Mahidol University Faculty of Science · Department of Mathematics

1990–

Chairman

Mahidol University Faculty of Science · Master of Science Program in Applied Mathematics

1990–

Asst. Chairman

Mahidol University Faculty of Science · Department of Mathematics

1989–

Assistant Professor

Mahidol University Faculty of Science · Department of Mathematics

1987–

Assistant Professor

Mahidol University Faculty of Science · Department of Physics and Mathematics

1977–

Lecturer

Mahidol University Faculty of Science · Department of Physics and Mathematics

Education

1985

Ph.D.

Vanderbilt University Vanderbilt Brain Institute · Mathematics

1978

M.Sc.

Australian National University · Applied Mathematics

1976

B.Sc. with A2 Honours

Australian National University · Applied Mathematics

Country

TH