Elevated Expression of
ADAM10
Induced by HPV E6 Influences the Prognosis of Cervical Cancer
Objective:
To explore the abnormal expression of
ADAM10
, its cause, and its clinical value in the prognosis of cervical lesions.
Methods:
The abnormal expression of
ADAM10
was explored using the Gene Expression Profiling Interactive Analysis database, and the abnormal expression in cervical lesions was verified using immunohistochemistry (IHC). The transfection effect of shRNA was evaluated using real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The expression of
ADAM10
in cells was analyzed using western blotting.
Results:
ADAM10
was highly expressed in multiple cancers. As the disease progressed, the expression of
ADAM10
gradually increased (
p
< 0.05). Patients with higher expression of
ADAM10
had poorer survival outcomes than those with lower expression levels (
p
< 0.05). The expression levels of
ADAM10
decreased after expression levels of E6 was inhibited.
Conclusion:
ADAM10
is highly expressed in cervical cancer; the higher the expression levels, the worse the survival outcome. HPV E6 is the critical driver of the elevated expression of
ADAM10
in cervical cancer.
