Wei Shi

The role of extracellular vesicles in the communication between endometrial cancer cells and tumour-associated macrophages: a review

Endometrial cancer is a significant threat to the health of women worldwide. Extracellular vesicles are essential for the proliferation, migration, and invasion of cancer cells, whereas tumour-associated macrophages (TAMs) are key regulators of cancer development. The interaction between macrophages and extracellular vesicles is also important in endometrial cancer. Extracellular vesicles from endometrial cancer cells can promote the polarization of macrophages towards an M2-like phenotype, and those from macrophages can also decrease the sensitivity of endometrial cancer cells to radiation. This paper presents a review of the various roles of extracellular vesicles in endometrial cancer and their potential as biomarkers and therapeutic targets. Research progress on the communication between endometrial cancer cells and tumour-associated macrophages mediated by extracellular vesicles is reviewed as well.

Detection of living cervical cancer cells by transient terahertz spectroscopy

AbstractThe photonic energy of terahertz wave is in the same order of magnitude as the rotational and vibrational energy levels of organic and biological macromolecules, so it has unique advantages in detecting cells and biological macromolecules. However, in the life environment, the dynamic time scale of cell‐environment interaction and structural conformation change of biological macromolecules are within picosecond to millisecond, and water has strong absorption to terahertz wave, which has become the bottleneck problem for the detection of cells and biological macromolecules by terahertz technology. In this article, we developed a set of terahertz single measurement system based on the tilt wave front of grating pulse technique. The system was employed for the terahertz detection of trace living cervical cancer cells. We achieved transient detection of the terahertz pulse time‐domain waveform of the living HeLa cells. The characteristic absorption peaks were identified by Lambert‐Beer law, respectively, at 0.49, 0.71, 1.04, 1.07, 1.26 and 1.37 THz. The absorbance is proportional to the cell concentration.