Investigator

Subhranshu Sekhar Kar

Associate Dean- Curriculum Development and Implementation, Professor of Pediatrics and Neonatology · Ras al-Khaimah Medical and Health Sciences University

About

SSKSubhranshu Sekhar…
Papers(1)
Molecular Basis of Hy…
Collaborators(5)
Manjunatha Goud Bella…Mohamed Anas Mohamed …Rajani DubeRasha Aziz Attia Sala…Shadha Nasser Mohamme…
Institutions(2)
College Of Medical Sc…Ras al-Khaimah Medica…

Papers

Molecular Basis of Hydatidiform Moles—A Systematic Review

Gestational trophoblastic diseases (GTDs) encompass a spectrum of conditions characterized by abnormal trophoblastic cell growth, ranging from benign molar pregnancies to malignant trophoblastic neoplasms. This systematic review explores the molecular underpinnings of GTDs, focusing on genetic and epigenetic factors that influence disease progression and clinical outcomes. Based on 71 studies identified through systematic search and selection criteria, key findings include dysregulations in tumor suppressor genes such as p53, aberrant apoptotic pathways involving BCL-2 (B-cell lymphoma), and altered expression of growth factor receptors and microRNAs (micro-ribose nucleic acid). These molecular alterations not only differentiate molar pregnancies from normal placental development but also contribute to their clinical behavior, from benign moles to potentially malignant forms. The review synthesizes insights from immunohistochemical studies and molecular analyses to provide a comprehensive understanding of GTD pathogenesis and implications for personalized care strategies.

84Works
1Papers
5Collaborators
Polycystic Ovary SyndromeUterine Neoplasms46, XX Disorders of Sex DevelopmentSandhoff Disease

Positions

2023–

Associate Dean- Curriculum Development and Implementation, Professor of Pediatrics and Neonatology

Ras al-Khaimah Medical and Health Sciences University

2015–

Professor

Ras Al Khaimah Medical and Health Sciences University · Paediatrics and Neonatology

2017–

Associate Dean

Ras Al Khaimah Medical and Health Sciences University · Clinical Sciences

2011–

Associate Professor

Ras Al Khaimah Medical and Health Sciences University · Paediatrics

2010–

Associate Professor

Hitech Medical College and Hospital · Paediatrics and Neonatology

2005–

Assistant Professor

Hitech Medical College and Hospital · Paediatrics and Neonatology

2005–

Registrar/ Fellow PICU

Kanchi Kamakoti Childs Trust Hospital · Paediatrics-PICU

2004–

Senior Resident

Hitech Medical College and Hospital · Paediatrics and Neonatology

Education

2025

PG Diploma in Medical Education

Warwick University · MSc Medical Education for Healthcare Professionals

2023

FELLOW-NEONATAL MEDICINE

Emergency Crisis Management Solution, STATPEARLS,USA AND LearnEM, Australia · Neonatal Medicine, Neonatal acute and critical care

2023

Fellow-Neonatal Medicine

STATPEARLS,USA and LearnEM-ECMS · Neonatal acute and Critical care

2004

M.D.Student/P.G.Student/Junior resident-acdemic

Sriram Chandra Bhanja Medical College and Hospital · Paediatrics and Neonatology

1999

Internship - MBBS

Maharaja Krishna Chandra Gajapati Medical College and Hospital · Internship

1998

MBBS

Maharaja Krishna Chandra Gajapati Medical College and Hospital · MBBS

1992

Higher secondary / +2 Science

Council of Higher Secondary Education · CHSE

1990

High school certificate /Secondary/ Matriculation

Board of Secondary Education · BSE

Country

AE

Keywords
PediatricsNeonatologyPediatric Critical CareMedical EducationPediatric respiratory careEvidence based MedicineGenetics and DysmorphologyCommunity PediatricsFetal MedicinePediatric Cardiology
Links & IDs
0000-0002-9379-7447