Investigator

Siew-Kee Low

Group Leader · Japanese Foundation for Cancer Research, Cancer Precision Medicine Center

Research Interests

SLSiew-Kee Low
Papers(1)
GWAS of five gynecolo…
Collaborators(2)
Yoichiro KamataniYukinori Okada
Institutions(2)
Riken Center For Inte…The University of Tok…

Papers

GWAS of five gynecologic diseases and cross-trait analysis in Japanese

We performed genome-wide association studies of five gynecologic diseases using data of 46,837 subjects (5236 uterine fibroid, 645 endometriosis, 647 ovarian cancer (OC), 909 uterine endometrial cancer (UEC), and 538 uterine cervical cancer (UCC) cases allowing overlaps, and 39,556 shared female controls) from Biobank Japan Project. We used the population-specific imputation reference panel (n = 3541), yielding 7,645,193 imputed variants. Analyses performed under logistic model, linear mixed model, and model incorporating correlations identified nine significant associations with three gynecologic diseases including four novel findings (rs79219469:C > T, LINC02183, P = 3.3 × 10

28Works
1Papers
2Collaborators
Breast NeoplasmsBiomarkers, TumorNeoplasmsDrug Resistance, NeoplasmEndometriosisLung Neoplasms

Positions

2017–

Group Leader

Japanese Foundation for Cancer Research · Cancer Precision Medicine Center

2015–

Lecturer

The University of Sydney · Faculty of Pharmacy

2014–

Research Scientist

The Institute of Physical and Chemical Research (RIKEN) · Laboratory for Statistical Analysis, Core for Genomic Medicine, Center for Integrative Medical Sciences

2012–

Postdoctoral fellows

The Institute of Physical and Chemical Research (RIKEN) · Laboratory for Statistical Analysis, Core for Genomic Medicine, Center for Integrative Medical Sciences

2011–

Postdoctoral fellows

University of Tokyo · Institute of Medical Sciences

Education

2011

Doctor of Philosophy (Ph.D) in Medical Genomics

University of Tokyo · Graduate School of Frontier Sciences

2006

Master of Science (Disctinction)

University of Malaya · Faculty of Science

2003

Bachelor Of Biomedical Sciences (First Hon.)

University of Malaya · Faculty of Medicine

Country

JP

Keywords
Personalized medicineGenomegenome-wide association studynext generation sequencing
Links & IDs
0000-0003-2386-0698