S.E. Krasil’nikov

Endometrial vascularisation in hyperplasia without atypia

Various benign processes in the endometrium are the cause of vascular changes. Endometrial cancer is also accompanied by changes in the density of microvessels. The detection of vascularization of the hyperplastic endometrium without signs of atypia, expressed significantly more than described in the literature, served as the basis for this work. Objective. To assess the state of the vascularization of the simple endometrial hyperplasia without atypia and to compare the obtained results with literary data. Material and methods. Vascularization of the endometrium in its simple hyperplasia without atypia was studied in 31 women by light microscopy using an immunohistochemical reaction with antibodies to the CD34 antigen and morphometry. Results. Different patients had different degrees of expression, but always large, vascularization of the endometrium with simple endometrial hyperplasia without atypia. The vessels accounted 5.97±4.18% of the section area, while their number per 1 mm2 was 391±180. These data significantly exceed most of the results of other studies presented in the literature, which differ several times even from each other. Conclusion. Endometrium with simple endometrial hyperplasia without atypia is characterized by different, often very high levels of vascularization, the real average values much exceed most of the literary data, which are also very contradictory. A very critical attention to the results describing the features of angiogenesis and vascularization of hyperplastic endometrium without atypia is necessary.