miR-21 and miR29-a: Potential Molecular Biomarkers for HPV Genotypes and Cervical Cancer Detection
Background and objective:
This study aimed to assess miR21 and miR-29a diagnostic
usefulness for HPV infection and Cervical Cancer (CC) detection.
Methods:
miRs extraction has been performed on HPV-positive, CC and negative control of 43, 50
and 46 individuals, respectively. The expression level of miRs has been analyzed using Real-Time
RT-PCR.
Results:
There was a correlation between the expression of miRs and the Receiver Operating Characteristic
(ROC) analysis in CC and HPV-positive patients.
Conclusion:
The correlation between expressions of miRs is notable. ROC curve analysis could be
applied in molecular diagnostic exposure for CC related to HPV infections.
