Investigator

Sabrina E. Wang

Research Fellow · The University of Sydney, The Daffodil Centre

SEWSabrina E. Wang
Papers(1)
The Effect of Circula…
Collaborators(8)
Tracy O'MaraVanessa Y. TanYadi ZhengJames YarmolinskyLaure DossusMarc J GunterMatthew A LeeNicholas J. Timpson
Institutions(5)
Unknown InstitutionQIMR Berghofer Medica…University Of BristolCentre International …Imperial College Lond…

Papers

The Effect of Circulating Proteins and Their Role in Mediating Adiposity’s Effect on Endometrial Cancer Risk: Mendelian Randomization and Colocalization Analyses

Abstract Background: Proteomics could enhance our understanding of endometrial carcinogenesis. However, addressing confounding in traditional observational studies remains challenging, especially given the strong impact of adiposity on the plasma proteome and endometrial cancer risk. Methods: Using Mendelian randomization (MR) and colocalization analyses, we examined the causal association between 2,751 unique proteins from the UK Biobank (N proteins = 2,031; N = 52,363) and deCODE (N proteins = 1,667; N = 35,559) with endometrial cancer risk [overall (N cases = 12,270; N controls = 46,126), endometrioid (N cases = 8,758), and nonendometrioid (N cases = 1,230)]. We performed enrichment analyses to explore pathways overrepresented among plasma proteins in endometrioid and nonendometrioid cancer subtypes. We assessed whether circulating proteins mediated the effect of body mass index on endometrial cancer risk using uni- and multivariable MR. Results: Twenty proteins were associated with endometrial cancer risk in MR and colocalization analyses. GSTO1-1 and SKAP1 were positively and MMP10 was negatively associated with overall and endometrioid endometrial cancer; DTYMK and ABO were positively and TSSC4 was negatively associated with overall endometrial cancer; IGF2R was positively associated with endometrioid cancer; and MAPK9 was positively and DNAJB14, IFI16, LCN2, and SCT were negatively associated with nonendometrioid endometrial cancer. Distinct pathways were overrepresented in endometrioid (e.g., platelet-derived growth factor signaling and PTEN gene regulation) and nonendometrioid (e.g., noncanonical NF-κB signaling) cancer subtypes. There was weak evidence of associated proteins mediating the relationship between body mass index and endometrial cancer risk. Conclusions: We identified distinct plasma proteins and pathways associated with endometrioid and nonendometrioid endometrial cancer risk. Impact: Prioritized proteins may support noninvasive methods to differentiate endometrial cancer subtypes.

30Works
1Papers
8Collaborators
Endometrial NeoplasmsBreast NeoplasmsEarly Detection of CancerOverdiagnosisGastritisHelicobacter Infections

Positions

2025–

Research Fellow

The University of Sydney · The Daffodil Centre

2023–

Postdoctoral Scientist

Centre international de recherche sur le cancer · Nutrition and Metabolism Branch

2022–

Research Assistant

Cancer Council Victoria · Cancer Epidemiology Division

2018–

Research Assistant

The University of Melbourne · Melbourne School of Population and Global Health

Education

2022

Doctor of Philosophy

The University of Melbourne · Melbourne School of Population and Global Health

2018

Master of Public Health

The University of Melbourne · Melbourne School of Population and Global Health

2014

Bachelor of Pharmacy

University of Queensland · School of Pharmacy