Investigator
Investigador auxiliar · University of Aveiro, Department of Chemistry
Discovery of Novel Fluorescent Azaindoles with Cytotoxic Action in A2780 Ovarian Carcinoma Cells
AbstractAzaindole scaffold is a privileged structure in medicinal chemistry and some derivatives have demonstrated to be potential anticancer drugs. Herein, a set of novel azaindoles, comprising the four regioisomers, bearing a morpholine (azaindoles 3 a‐d) and N‐methyl‐N‐benzylamine (azaindoles 4 a‐d) groups were prepared. Among these compounds, azaindoles 4 exhibited higher cytotoxicity against the ovarian cancer cell line A2780 and normal dermal fibroblasts compared to azaindoles 3. Furthermore, azaindoles 4 b and 4 c promoted a delay in the cell cycle of the cancer cell line, inspiring an investigation into the intracellular localization of these derivatives.
Investigador auxiliar
University of Aveiro · Department of Chemistry
Post-doctoral fellow
University of British Columbia · Department of Chemistry
PhD
Université Pierre et Marie Curie · Departemnt of Chemistry
Master
École Normale Supérieure · Department of Chemistry
Aggregation in "Sciences de la matière, option Chimie)
École normale supérieure de Lyon · Physical Sciences
Erasmus internship
Universiteit Leiden Leids Instituut voor Chemisch Onderzoek · Gorleaus laboratories
Master I
École normale supérieure de Lyon · Department of Chemistry
