Investigator
Fudan University Shanghai Cancer Center
[Retracted] The Promotional Effect of Hollow MnO2 with Brucea Javanica Oil Emulsion (BJOE) on Endometrial Cancer Apoptosis
Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO2 could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been illustrated to play a vital role in cancers. However, knowledge about the combined effect of H‐MnO2‐PEG/BJOE in endometrial cancer remains ambiguous up to now. In the present work, we prepared a drug‐delivery vector H‐MnO2‐PEG by chemical synthesis and found that H‐MnO2‐PEG significantly inhibited cell proliferation in endometrial cancer cells. Moreover, the combination of H‐MnO2‐PEG/BJOE could repress cell proliferation more efficiently and promote cell apoptosis. Mechanistically, we found that BJOE exerted its role as a promoter of endometrial apoptosis by regulating relative protein expressions. In general, the present study demonstrates that H‐MnO2‐PEG functions as a critical vector in the tumor microenvironment of endometrial cancer and the significant effect of H‐MnO2‐PEG/BJOE on cancer cells, suggesting a new paradigm for the treatment of endometrial cancer.
