Investigator

Prihantono Prihantono

Lecturer, Surgical Oncologist · Universitas Hasanuddin , Surgery

Research Interests

PPPrihantono Prihan…
Papers(2)
Comparison of Pain, C…Novel Complex of Zinc…
Collaborators(5)
Rizal IrfandiTria Astika Endah Per…Agussalim BukhariIndah RayaMochammad Hatta
Institutions(3)
Hasanuddin UniversityState University Of M…Universitas Muhammadi…

Papers

Novel Complex of Zinc (II) Dichloroethylenediamine: Synthesis, Characterization, In-silico, and In-vitro Evaluation against Cervical Cancer Cells

Cervical cancer is a malignancy originating from the cervix and often caused by oncogenic Human Papilloma Virus (HPV), specifically subtypes 16 and 18. Anticancer drugs are chemotherapeutic compounds used for cancer treatment. Therefore, this research aims to synthesize and characterize Zinc (II) dichloroethylenediamine (Zn(en)Cl2) complex, as well as determine its antiproliferative activity against HeLa cells. The Zn(en)Cl2 complex was successfully synthesized, and the antiproliferative activity was tested. The synthesis involved reacting ethylenediamine and KCl with Zn metal. The complex formed was characterized using a conductometer, UV-Vis spectroscopy, FT-IR spectroscopy, and XRD, while the activity was measured against HeLa cells. The synthesis yielded a 56.12% conversion with a melting point of 198-200 oC and a conductivity value of 2.02 mS/cm. The Zn(en)Cl2 complex showed potential activity against HeLa cells with an IC50 value of 898.35 µg/mL, which was evidenced by changes in the morphological structure of HeLa cells. Its interaction with DNA targets was investigated by employing molecular docking. The observed data indicated that the Zn(en)Cl2 complex bound to DNA at the nitrogenous base Guanine (DG) by coordinate covalent bonds. Interestingly, DG maintained interaction with the complex until the end of the docking simulation. Additionally, molecular dynamics (MD) simulation was conducted, and the results showed that Zn(en)Cl2 remained bound to the DNA binding pocket all through the process.

2Papers
5Collaborators
PrognosisBreast NeoplasmsApoptosisBiomarkers, TumorNeoplasm MetastasisNeoplasm Recurrence, LocalNeoplasm Staging

Positions

2008–

Lecturer, Surgical Oncologist

Universitas Hasanuddin · Surgery

2003–

Medical Doctor

Puskesmas Berbah · Medicine

2000–

medical doctor

Global Industries Asia Pacific Pte Ltd · medical

Education

2016

Surgical Oncologist

Universitas Hasanuddin Fakultas Kedokteran · Surgical Oncology

2012

Master of Health

Universitas Hasanuddin Fakultas Kedokteran · Biomedic

2011

General Surgeon

Universitas Hasanuddin Fakultas Kedokteran · Surgery

1999

MD

Universitas Diponegoro Fakultas Kedokteran · Medicine

Country

ID

Keywords
Breast cancerChemotherapyBiology MollecularmRNATOP2ABCL-2Ki-67DUSP4ERPRHER2