Phuc Nhon Nguyen

Efficacy of thermal ablation among women with cervical intraepithelial neoplasia grade 1 and high‐risk human papillomavirus genotypes: The first prospective study in Vietnam

Abstract Objective This study aimed to investigate the efficacy of thermal ablation (TA) for treating cervical intraepithelial neoplasia grade 1 (CIN 1) among women with positive high‐risk human papillomavirus (hr‐HPV). Methods This prospective study was conducted at Tu Du Hospital, Vietnam between August 2023 and February 2025. The study enrolled all the women aged greater than 30 years with CIN 1 and positive hr‐HPV test treated with TA. The primary outcome included evaluation of healed lesion on cytology, colposcopy combined with visual inspection of the cervix with acetic acid (VIA) and Lugol's iodine testing as well as HPV clearance rate. The secondary outcome included patient's satisfaction and undesirable effects during the treatment and follow‐up visits. Results Among 66 women eligible for inclusion in the study, the clearance rate of all hr‐HPV genotypes at 3 and 6 months was 62.1% and 84.6%, respectively. The clearance rates of HPV 16 and HPV 18 after undergoing TA treatment was highly achieved at 88.8% and 85.7%, respectively. Overall, the clearance rate of HPV 16, 12 other hr‐HPV genotypes, overall hr‐HPV genotypes and normal colposcopic findings were significantly improved following treatment compared to before treatment ( P  < 0.05). After 6 months, the overall cure rate of thermal ablation was observed at 60.6% (40/66 cases). The most common side effects included vaginal heat (43.1%), abdominal pain (34.8%), and vaginal pain (27.9%). On monitoring, patient's satisfaction was highly achieved at 93.9% on day 0 post‐treatment and for 95.5% at 3‐month control visit. No adverse effects as well as requirement of repeated ablation were reported. Conclusions Thermal ablation is an effective, safe, and well‐tolerated treatment for women with CIN 1 and positive hr‐HPV genotypes. This reliable modality shows a promising option for cervical cancer prevention in low‐resource settings. Further studies are required to strengthen these findings in different populations.

Assessing the Clinical Characteristics and the Role of Imaging Modalities in Uterine Sarcoma: A Single‐Center Retrospective Study From Vietnam

ABSTRACTBackgroundThis study aims to describe the clinical and imaging characteristics of uterine sarcomas and the role of imaging modalities in assessing them.Materials and MethodsThis retrospective study enrolled all patients diagnosed with uterine sarcoma at Tu Du Hospital, Vietnam between January 2020 and December 2023. The findings of ultrasound (US) and magnetic resonance imaging (MRI) were compared to histology as the reference.ResultsAmong 78 patients, 46.2% of cases were menopause. Abnormal vaginal bleeding was the most common symptom. Three common types of uterine sarcoma were leiomyosarcoma (50.0%), low‐grade endometrial stromal sarcoma (23.1%), and carcinosarcoma (19.2%). Some imaging features of uterine sarcomas were found including nontypical lesion of fibroid (89.7%), solitary mass (84.6%), inhomogeneous structure (76.9%), invisible endometrium (67.9%), moderate‐rich vascularization on Doppler signal (57.7%), irregular border of tumor (48.7%), classification of FIGO 0 (44.9%), cystic area within tumor (42.3%), acoustic shadowing (34.6%), “cooked” appearance (9.0%), and calcification image in tumor (6.4%). The sensitivity of standard US, consultant US, and MRI was 56.4%, 88.4%, and 87.5%, respectively.ConclusionsBesides clinical presentations, uterine sarcomas present some specific features on US. Consultant US and MRI could be added to standard US to increase the accuracy and help in surgical decision making where applicable.

Modified abdominal radical trachelectomy used to spare fertility during surgery for early-stage cervical cancer: a case report

Cervical cancer is the fourth most common malignant tumor in childbearing-age women. To date, cervical resection and fertility-sparing surgery are the trends in the era of minimally invasive management. However, a proper management remains crucial. Hereby, we endeavor to underscore an uncommon case of early-stage cervical cancer receiving a tailored surgical technique of abdominal radical trachelectomy at our tertiary referral center and review literature. A 33-year-old Vietnamese female patient (E1) was hospitalized for a diagnosis of cervical cancer classified as IB1 stage. The patient was treated with fertility-sparing modified abdominal radical trachelectomy surgery. The postoperative outcome was completely favorable. The patient was sent home after 5 days of hospitalization. In addition, she was monitored without complications. Fertility-preserving treatment could be effectively performed with a modified technique of abdominal radical trachelectomy among young women with early-stage cervical cancer. Interdisciplinary management is potentially necessary for favorable outcome. Further data are required for long-term outcomes of pregnancy, recurrent rate, and the risk of pelvic organ prolapse.