Investigator

Pablo Agustin Vargas

Professor · Universidade Estadual de Campinas, Oral Diagnosis

About

PAVPablo Agustin Var…
Papers(1)
Histopathological ris…
Institutions(1)
Universidade Estadual…

Papers

Histopathological risk assessment in multisite epithelial dysplasia: A meta‐analysis

Abstract Objective Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes. Methods The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design. Results Forty‐six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta‐analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia. Conclusions No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.

463Works
1Papers
Mouth NeoplasmsHead and Neck NeoplasmsOdontogenic TumorsCarcinoma, Squamous CellBiomarkers, TumorPrognosisNeoplasm Recurrence, Local

Positions

1997–

Professor

Universidade Estadual de Campinas · Oral Diagnosis

Education

2014

Extraordinary Professor

University of Pretoria · Oral Biology and Oral Patholgy

2013

FRCPath

Royal College of Pathologists

2007

Pos-doctoral study

University of Sheffield · Oral Pathology

2001

Estágio

Universidade de São Paulo Faculdade de Medicina · Pathology

1999

PhD

Universidade Estadual de Campinas · Oral Diagnosis

1995

Dentist

Universidade Estadual Paulista Júlio de Mesquita Filho · Dentistry

Country

BR

Keywords
oral pathology