OKOmar Kujan
Papers(1)
Histopathological ris…
Collaborators(10)
Pablo Agustin VargasSusanna JuteauTuula Anneli SaloAlan Roger Santos‐Sil…Brunno Santos de Frei…Caique Mariano PedrosoDaniel Lobato Ferreir…Erison Santana do San…Marcio Ajudarte LopesMohammed I. Malki
Institutions(6)
The University Of Wes…Universidade Estadual…University Of HelsinkiUniversity of HelsinkiUniversidade Federal …Qatar University

Papers

Histopathological risk assessment in multisite epithelial dysplasia: A meta‐analysis

Abstract Objective Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes. Methods The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design. Results Forty‐six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta‐analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia. Conclusions No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.

197Works
1Papers
10Collaborators
Mouth NeoplasmsHead and Neck NeoplasmsMouth DiseasesPrecancerous ConditionsPrognosisCytodiagnosis

Positions

Researcher

The University of Western Australia

2016–

Senior Lecturer in Oral Pathology

University of Western Australia · School of Dentistry

2011–

Assisstant Professor/ Head Unit of Continuing Education

Al-Farabi College · Oral and Maxillofacail Sciences

2007–

Assistant Professor / Head of Department

Al-Baath University Faculty of Dentistry · Oral Pathology

2006–

Researcher

Guy's and Saint Thomas' NHS Foundation Trust · Oral Pathology

2006–

Clinical Research Fellow

University of Manchester · Oral Pathology

Education

2006

PhD

University of Manchester School of Dentistry · Oral Medicine and Oral Pathology

Keywords
OralCancerPrecancerDentistryScreeningMolecular biologyTeachingevidence-based researchoral pathology and medicine