Investigator
principal research investigator · Biomedical Research Center, Institute of Clinical and Translational Research
Calcium signaling affects migration and proliferation differently in individual cancer cells due to nifedipine treatment
Several papers have reported that calcium channel blocking drugs were associated with increased breast cancer risk and worsened prognosis. One of the most common signs of breast tumors is the presence of small deposits of calcium, known as microcalcifications. Therefore, we studied the effect of dihydropyridine nifedipine on selected calcium transport systems in MDA-MB-231 cells, originating from triple negative breast tumor and JIMT1 cells that represent a model of HER2-positive breast cancer, which possesses amplification of HER2 receptor, but cells do not response to HER2 inhibition treatment with trastuzumab. Also, we compared the effect of nifedipine on colorectal DLD1 and ovarian A2780 cancer cells. Both, inositol 1,4,5-trisphosphate receptor type 1 (IP
principal research investigator
Biomedical Research Center · Institute of Clinical and Translational Research
Researcher
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences · Department of Cell Physiology and Genetics
Ph.D.
Faculty of Chemical Technology, Slovak Technical University · Department of Biochemistry
SK
