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Investigator

Niki L. Dimou

Statistician on the project entitled “European MSM Internet Survey in Greece”. · Positive Voice

Research Interests

Papers

Circulating adipokine concentrations and risk of five obesity‐related cancers: A Mendelian randomization study

AbstractObesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence indicates that circulating adipokines may be associated with the development of obesity‐related cancers, but it is unclear if these associations are causal or confounded. We examined potential causal associations of specific adipokines (adiponectin, leptin, soluble leptin receptor [sOB‐R] and plasminogen activator inhibitor‐1 [PAI‐1]) with five obesity‐related cancers (colorectal, pancreatic, renal cell carcinoma [RCC], ovarian and endometrial) using Mendelian randomization (MR) methods. We used summary‐level data from large genetic consortia for 114 530 cancer cases and 245 284 controls. We constructed genetic instruments using 18 genetic variants for adiponectin, 2 for leptin and 4 for both sOB‐R and PAI‐1 (P value for inclusion<5 × 10−8). Causal estimates were obtained using two‐sample MR methods. In the inverse‐variance weighted models, we found an inverse association between adiponectin and risk of colorectal cancer (odds ratio per 1 μg/mL increment in adiponectin concentration: 0.90 [95% confidence interval = 0.84‐0.97]; P = .01); but, evidence of horizontal pleiotropy was detected and the association was not present when this was taken into consideration. No association was found for adiponectin and risks of pancreatic cancer, RCC, ovarian cancer and endometrial cancer. Leptin, sOB‐R and PAI‐1 were also similarly unrelated to risk of obesity‐related cancers. Despite the large sample size, our MR analyses do not support causal effects of circulating adiponectin, leptin, sOB‐R and PAI‐1 concentrations on the development of five obesity‐related cancers.

106Works

1Papers

6Collaborators

Colorectal NeoplasmsEndometrial NeoplasmsMental DisordersKidney NeoplasmsBiomarkers, TumorCarcinoma, Squamous CellHead and Neck Neoplasms

Positions

Statistician on the project entitled “European MSM Internet Survey in Greece”.

Positive Voice

Statistician on the project entitled "External evaluation of the actions to strenghthen the operational capacity of the labour institute of the General Confederation of Workers in Greece".

CMT Prooptiki L.T.D.

2019–

Postodoctoral researcher

International Agency For Research On Cancer

2017–

Postdoctoral researcher on the project entitled “Genetic epidemiology of sex steroid hormones and cancer”

University of Ioannina

2017–

Statistician on the project entitled “Genetic factors for osteoporosis (GEFOS)”

University of Ioannina

2016–

Researcher-statistician on the project entitled “Comprehensive assessment, validation and causal identification of dietary exposures and cancer risk”

University of Ioannina

2016–

Statistician on the project entitled “Genetic factors for osteoporosis (GEFOS)”

University of Ioannina

2015–

InuStatistician on the project entitled "Pilot system for recording patient’s data".

University of Thessaly

2015–

Biostatistician on the project entitled "Intervention for the early diagnosis of mesothelioma in populations exposed to asbestos by using novel biomarkers".

National School of Public Health

2015–

Statistician on the project entitled "External Evaluation of Intercultural Education Actions".

CMT Prooptiki L.T.D.

2014–

Researcher-biostatistician on the project entitled “Integration of data from multiple sources: a fusion of epidemiology and bioinformatics with applications to complex diseases”.

University of Thessaly

2014–

Researcher-biostatistician on the project entitled “Modern bioinformatics techniques in studying the mechanism of action of membrane receptors and their implications in human diseases.”

University of Thessaly

2014–

Researcher-biostatistician on the project entitled “Catholic Multidisciplinary Prevention Intervention on Smoking and Health Promotion for students of Primary and Secondary Education”.

CMT Prooptiki L.T.D.

2013–

Researcher-biostatistician on the project etitled “Oral Health Study.”

Euroconsultants S.A.

2012–

Statistician on the project entitled “Implementation of actions to meet the medical and psychosocial needs of third-world immigrants without legal documentations that might otherwise need international protection in the region of Evros.”

Hellenic Center for Disease Control & Prevention

2009–

Biostatistician on the project entitled “Genetic Epidemiology of metabolic syndrome”.

University of Thessaly

Education

2016

PhD in Genetic Epidemiology

Department of Computer Science and Biomedical Informatics, University of Thessaly

2011

MSc in Biostatistics

Department of Mathematics and Medical School, University of Athens

2009

BSc in Biology

Department of Biology, University of Athens

Links & IDs

0000-0003-1678-9328 scholar.google.com