How are researcher profiles built on OCRA?

Profiles are constructed from ORCID records, PubMed author data, and institutional affiliations via ROR. Each profile includes a MeSH-based research expertise map derived from the researcher's publication history.

Can I find collaborators in a specific research area?

Yes. Browse investigators by research focus, institution, or MeSH expertise. Co-author networks and shared study participation help identify potential collaborators in gynecologic oncology.

What is the MeSH expertise profile on each researcher page?

The MeSH profile summarizes a researcher's publication topics using Medical Subject Headings. It shows the diseases, techniques, and chemicals most frequently associated with their published work.

Investigator

Nazariy Pokhodylo

Professor · Ivan Franko National University of Lviv, Department of Organic Chemistry

Papers

Extract of Indigofera spicata Exerts Antiproliferative Effects on Human Colorectal and Ovarian Carcinoma Cells

Metabolic anticancer therapy based on enzymatic arginine (Arg) deprivation (ADT) is currently being evaluated in clinical trials. The combination of ADT with low doses of the plant cytotoxic analogs of Arg, canavanine (Cav) or indospicine (Isp), have been proposed as being more efficient and selective against malignant cells. The leguminous plant Indigofera spicata contains one of the highest known amounts of Isp. Here we demonstrate for the first time that the Isp-containing ethanolic extract from I. spicata is growth-inhibiting and toxic for cultured human colorectal and ovarian carcinoma cells. The extract reduces the viability of colorectal carcinoma cells two-fold under Arg-deficient conditions and entirely abrogates their residual proliferative potential (growth recovery) after the treatment. Pre-exposure of the extract to recombinant human arginase I (rhARGI) as a therapeutic Arg-depleting agent did not impact the extract’s efficacy. Further development of Isp as a component of combinatorial anticancer metabolic targeting strategies is discussed.

136Works

1Papers

7Collaborators

Ovarian NeoplasmsCell Line, TumorColorectal Neoplasms

Positions

2025–

Professor

Ivan Franko National University of Lviv · Department of Organic Chemistry

2023–

Leading Researcher (part-time)

Ivan Franko National University of Lviv

2023–

Associate Professor

Ivan Franko National University of Lviv · Department of Organic Chemistry

2021–

Associate Professor (part-time)

Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv · Department of Pharmacy and Biology

2019–

Leading Researcher

Ivan Franko National University of Lviv

2016–

Scientific consultant (freelance)

Novartis Biomedical Research Institute

2016–

Senior Researcher

Ivan Franko National University of Lviv

2014–

QА Auditor (QA Engineer)

PJSC “Halychfarm”, Arterium Corporation

2013–

Freelance Scientist

Curplyx DRS (Scientific Service Company)

2010–

Senior Researcher

Lviv University

2010–

Freelance Scientist

LLC "NSF OTAVA" (Scientific Service Company)

2008–

Assistant Professor

Ivan Franko National University of Lviv · Department of Organic Chemistry

2007–

Junior Researcher

Ivan Franko National University of Lviv

Education

2018

Doctor of Science (Chemistry)

Ivan Franko National University of Lviv

2015

Specialist in the Economics of Enterprise

Ivan Franko National University of Lviv · Enterprise Economics

2007

Candidate of Science (Chemistry) / PhD in Chemistry

Ivan Franko National University of Lviv

2004

Master of Science in Chemistry

Ivan Franko National University of Lviv · Faculty of Chemistry

2003

Bachelor of Science in Chemistry

Ivan Franko National University of Lviv · Faculty of Chemistry

Country

Keywords

organic chemistrybiomoleculesmedical chemistry

Links & IDs

0000-0001-8222-5008

Scopus: 21934949900

Researcher Id: K-9241-2017